Benefits of Mega Leucin 900:
Unique amino acid to enhance musle building and to protect lean muscle mass
Muscle tissue is made of 80 % BCAAs, and these are preferentially broken down (in terms of amino acids) during exercise. Thus, by supplying an outside source of BCAAs such as leucine, you can spare your own muscular stores. The same applies to dieting conditions.It has been known for some time that consuming a complete meal stimulates protein synthesis. Research has revealed that amino acids are responsible for 80 % of the protein synthesis which occurs after feeding. It also reveals that out of all the amino acids only one is able to stimulate protein synthesis by itself - L-leucine.
How does leucine effect protein synthesis?
Protein synthesis refers to the process of constructing new proteins. It is accomplished by first copying instructions from DNA onto an mRNA molecule (transcription). Following the mRNA is taken into the cells interior and attached to complex machinery known as the Ribosome, and its accompanying ribosomal proteins. Once attached a new protein is constructed, and this process is known as translation.
Protein synthesis can change rapidly during exercise, after feeding, and during fasting conditions such as when you sleep at night. The evidence is clear that these rapid changes occur at the beginning stages of translation, known as translation initiation.
Translation is controlled by a family of proteins known as initiation factors. For example they are responsible for binding mRNA to a ribosome (e.g. attaching the instructions for building a protein to the machinery responsible for building the protein). Increased leucine concentration leads to an increase in the formation of these initiation factors. Leucine also activates a protein known as ribosomal protein S6, which actually stimulates production of more initiation factors and other ribosomal proteins. In other words S6 increases the capacity of a cell to produce proteins.
Leucine does not directly stimulate any of these processes. Instead increased concentrations of leucine activate a molecule known as Mammalian target of rapamycin (mTOR). This cellular machine ends out activating the initiation factors and increasing a cells capacity to increase protein synthesis. The amazing thing is that mTOR is sensitive to leucine concentration, growth factors released from exercise, energy status in the cell, and insulin concentrations. Therefore for protein synthesis to act optimally it requires an interaction between all of these factors. In summary increased leucine concentration activates mTOR, which activates protein synthesis, and increases a cells capacity to produce new proteins.
What is Leucine´s Role in regulating protein degradation (breakdown)?
Leucine´s primary role appears to be increasing protein synthesis. But recall that muscle growth is the difference between protein synthesis and breakdown (degradation). Leucine appears to decrease protein breakdown. For example leucine has lowered markers of muscle damage in both resistance training and endurance conditions. There are a number of theories as to why this occurs.
Leucin is also a precurser for HMB, which is mainly known as an inhibitor of protein breakdown. It has been demonstrated to decrease muscle loss in both exercise and clinical conditions. The only problem is that only 2-10 % of leucine is converted to HMB. Yet, if you analyze a bodybuilder´s diet, which frequently consists of 200 to 300 grams a day of protein, it is conceivable that this is how it is eliciting some of its effects. This would amount to 20 to 30 grams of leucine. If the average of 5 % were converted then this would give a range of 1 to 1.5 grams of HMN, and if the maximum were converted it would give a range of 2-3 grams of HMB daily. If an individual is supplementing with EAAs rich in leucine the numbers can increase. In summary leucine probably acts through both indirect (HMB) and direct mechanisms.
Leucine also has several other functions including regulating the hormone insulin, controlling protein breakdown rates, stabilizing blood glucose levels, along with a host of other functions.
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